Endosomal Escape: Unlocking Critical Hurdles of Intracellular Delivery
How Endosomal Escape Determines Success in Modern Medicine The “Endosomal trap” is responsible for eliminating 90–99% of the administered vaccine dose, resulting in low therapeutic potency, dose inefficiency, and limited clinical translation. When nanoparticles, viral vectors, and lipid carriers are taken into membrane-bound endosomes, these are sent to lysosomal degradation if the therapeutic cargo does […]