Circular RNA – Exploring New Potentials Beyond the Loop
Circular RNAs (circRNAs) are a specific group of non-coding RNAs that are present in a structural covalently closed loop and do not exhibit distinct five caps and 3poly (A) tails like linear RNAs. It was first identified as a structural element in viroids in 1976, where circRNAs lay unnoticed for nearly two decades until they […]
Beyond mRNA: How CircRNA Is Disrupting The Therapeutic Paradigm
Circular RNAs (CircRNA) are a naturally occurring, large family of stable single-stranded RNAs. They are a strongly emerging category in RNA therapeutics and are expected to outgrow their linear counterparts due to their low immunogenicity, higher stability, and stronger protein expression. Early research has scratched only the tip of the iceberg in the last few […]