Next-gen Longevity Beauty Ingredients: The Future Of Formulations

Beauty longevity marks a paradigm shift in aesthetics philosophy as it finally focuses on the cause rather than the symptoms of aging. We are finally entering an era where scientific advancements aim to slow down or reverse skin aging, rather than just alleviate its symptoms. It is now clear that aging hallmarks encompass a wide array of cellular processes, including telomere attrition, proteostasis loss, genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence, and altered intercellular communication.

Therefore, the ingredients needed to counter these processes must also be specific to an individual’s physicochemical, genetic, and cellular profiles. Since this trend is part of the broader growing inclination towards personalized beauty solutions, formulators must work proactively to align with this shift. In lieu of that, we have assembled a list of next-generation ingredients that will serve as differentiators in this intensely competitive segment in the years to come. 

Next-gen Beauty Longevity Ingredients that Deserve Acknowledgment in the Cosmetics Industry

Aethelis Granata

Introduced by Naolys, Aethelis Granata is a pomegranate-derived exosome that enhances chromatic organization, intercellular communication, DNA repair processes, and mitochondrial energy, paving the way for resilient skin. Naolys is a French company that leads the plant cell culture industry and holds a reputation for its expertise in natural cosmetic actives. It is currently offering Aethelis Granata at a starting concentration of 0.5% and claims that the ingredient is ideal for advanced skincare applications for skin longevity. The ingredient can be integrated into products designed to support skin homeostasis and revive skin through cellular regeneration optimization.

Cellaigie

LipoTrue’s cellaigie is an AI-designed peptide activating autophagy. It is about to debut in Amsterdam this year at the In-cosmetics Global 2025. The ingredient takes inspiration from High-Intensity Interval Training (HIIT) and fasting. It triggers autophagy, a natural skin regeneration process that involves the recycling of damaged cellular entities. Cellaigie mimics the cellular energy efficiency and resilience resulting from fasting and HIIT. The ingredient promises a refreshed, youthful appearance to its users.

Oximony

A BASF product, Oxymony™, is an innovative plant-derived ingredient that targets multiple hallmarks of aging. It has the potential to combat cellular senescence, stimulate taurine production, and reduce oxidative stress. Simultaneous targeting of these skin fatigue symptoms helps rejuvenate the skin, enhancing its glow and firmness, and leading to a revitalized appearance and complexion.  It is a special formulation that is colorless, pH-tolerant, cation-compatible, and ideal for use in solid formulations. A 100 percent natural ingredient that is compliant with ISO 16128-2 and is fully or partially soluble in alcohol. 

Schisandra Chinensis Extract

Marketed as URBALYS and TIMELYS, this Greentech product targets interconnected skin longevity mechanisms. Derived from concentrated Schisandrin Chinensis Superberry, it has been classified as a superior medicine. The molecule has been specifically recognized for its ability to support longevity genes, optimize interconnected cellular functions, and preserve skin quality. The list of its applications includes positive skin care, preventive skin care, and moisturization. The ingredient is testament to GREENTECH’s aim to step up its commitment to beauty longevity. 

Clarivine

Another ingredient inspired by the benefits of intermittent fasting, Clarivine initiates crucial cellular mechanisms that trigger the skin’s regeneration process, resulting in a radiant and healthier appearance. This Vytrus Biotech product is a biotechnology active ingredient extracted from the Vitis vinifera flower. It produces high quantities of secondary metabolites and polyphenols that help skin thrive under stress through potent self-preservation processes. Vytrus recreated intermittent fasting conditions in the flower stem cell cultures, uncovering a new signaling pathway for resveratrol that acts as both a modulator of longevity pathways and a potent oxidant.  Its key applications include exosome-based skincare, peptide- and resveratrol-based skincare, skin brightening and refinement, anti-aging treatments, hydration, and detox-boosting formulations. 

Pro-Longevia

Introduced by Solabia, pro-longeia is a plant-derived active ingredient that promises to maintain skin integrity while addressing signs of aging. Derived from organic raspberry leaves, it targets the most crucial cellular signaling pathways, including mitochondrial antioxidant autophagy, DNA repair, and proteostasis defense, which help maintain cellular structural integrity. Pro-Longevia supports skin resilience and vitality by safeguarding bioenergetic efficiency, restricting cell senescence, and stimulating epidermal regeneration. It is specifically designed to rejuvenate the eye contour area and enhance skin texture. A 100 percent natural origin ingredient that complies with ISO 16128.

Scientific Drivers

• NAD+ Optimization: Nicotinamide adenine dinucleotide (NAD) is crucial to human body development. It plays a crucial role in slowing down the hallmarks of aging by activating the sirtuin enzyme SIRT1, a gene associated with longevity. It is a natural molecule present in living cells that regulates cellular aging and helps proper body functioning. Its levels decrease as the body ages, implying that reviving NAD+ levels could be key to enhancing longevity, boosting cellular function, and improving energy production.
• Autophagy Activation: It is being leveraged for its critical role in cellular rejuvenation, energy homeostasis, cellular repair, and the regulation of cellular aging. Autophagy activation helps remove damaged cellular organelles, enhances skin defenses, and contributes to younger-looking skin. 
• Epigenetic Regulation: It is the new avenue for understanding and manipulating the aging process at the most basic level. Targeting epigenetic modifications, such as histone acetylation and DNA methylation, may be crucial in reversing the changes resulting from aging processes and promoting skin rejuvenation. 

The Final Word

As new research and innovations navigate the uncharted waters of beauty longevity, a number of factors still need to be considered. There are still challenges that formulators need to address. From approval complexities to cost barriers, formulation complexities, and sustainability trade-offs, there is still a long way to go. Consumer skepticism remains a significant gap that needs to be bridged.

Almost 65-70% of consumer demand clinical validation of longevity claims, which mandates costly trials for the brands. Lastly, integration challenges persist, and strategic considerations remain a long shot. Higher investments are needed to support AI-driven formulations, adopt hybrid approaches, and co-branding with nutraceuticals.