Future of Synthetic Food Colors: Beyond Petroleum-based Dyes

  • May 14, 2025
  • 5 min, 0 sec

As the US FDA decides to phase out petroleum-based food dyes by the end of 2026, a bigger question emerges on how this decision will reshape the future of food coloring. For now, they have decided to follow a series of measures for the systematic removal of certain synthetic food dyes from the national supply chain. 

However, to understand or infer the future impact of this move, it is equally important to understand the causes that led to this decision and what kind of alternatives are currently available to substitute these pigments on an industrial level.

In the following sections, we will be picking up the reasons, the impact, and the result of this decision, along with some recommendations for food manufacturers to navigate this change. 

What Does the FDA Decision Entail? 

The U.S. Department of Health & Human Services and the FDA have taken this decision as part of the Make America Healthy Again initiative. This decision came to light after conclusions drawn from certain studies conducted on synthetic food dyes and their neurobehavioral impact on children. The California Office of Environmental Health Hazard Assessment (OEHHA) systematically reviewed 27 clinical trials of kids exposed to artificial food colors. Out of these 27 clinical trials, 25 were challenge studies. 

The study revealed that 64% of the 25 challenge studies showed a positive association between behavioral disorders and synthetic food pigments. It also revealed that the present acceptable daily intakes of these substances among children were based on outdated studies that could not identify the behavioral impact of these dyes. 

For now, the US FDA has banned the following list of food colorings from the national food supply chains: 

Food Dye NameCommon NameCommonly Found in the Present Array of Foods & Beverages
FD&C Red No. 40 Allura RedCandies (Skittles, M&M’s), cereals, sports drinks (Gatorade), frostings, condiments, gelatin, jams, sodas, pastries, pet foods
FD&C Yellow No. 5 TartrazineCandies, cereals, soft drinks (Mountain Dew), popcorn, yogurt, juices, spices, chips, baked goods, and sauces
FD&C Yellow No. 6(Sunset YellowCandies, sauces, baked goods, preserved fruits, cheese, soups, cereals, chips, beverages
FD&C Blue No. 1 Brilliant Blue FCFIce cream, canned peas, soups, popsicles, icing, confections, dairy products, candies (M&M’s), beverages
FD&C Blue No. 2 Indigo CarmineCandies, ice cream, cereals, snacks, sausages, maraschino cherries, beverages
FD&C Green No. 3 Fast Green FCFCanned vegetables, cereals, candies, ice cream, salad dressings, soft drinks, and popsicles
Citrus Red No. 2Usually used to render color to the skin of Florida oranges 
Orange BCommonly used in sausage and  hot dog casings 
Artificial Food Colors being Phased Out in the US Market by the end of 2026

What Kind of Health Risks are Strongly Associated With Petroleum-based Food Dyes?

  • Red 40: Red 40 is usually used in bright red frostings and rainbow sprinkles, and research suggests that, along with sugar, they are also the culprits for hyperactivity in kids. It is also associated with microbiome disruption, colon inflammation, DNA damage, and benzene contamination, along with ADHD symptoms in kids. 
  • Yellow 5: Processed in brightly colored soda, colored candy, and pastries, yellow No. 5 has also been associated with behavioral issues in kids. Just like red 40, it has also been associated with colon cancer risk, allergic reactions, and DNA damage in WBCs (white blood cells). 
  • Yellow 6: Usually used in beverages, sodas, and a few other edibles for color enhancement, yellow no. 6 has been associated with hormone disruption, benzidine contamination, testicular tumors in rats, and neurotoxicity. 
  • Blue 1 / 2: Used in specific food items, pharmaceuticals, and cosmetics, studies have established its relationship with organ damage, metabolic acidosis in terminally sick patients, and neurotoxicity. 
  • Citrus Red No.2: It is known to have several carcinogenic properties. 

What Kind of Alternatives can Replace Petroleum-based Artificial Food Colors?

A number of alternatives are already making rounds as alternatives to synthetic pigments. Broadly, they can be classified into synthetic and natural food coloring agents. Here is a closer look: 

FDA-Approved Synthetic Alternatives

  • Calcium Phosphate: An odorless, colorless, tasteless, non-toxic substance, it is deemed a safe and versatile additive for edibles. Alongside, it can enhance food’s structure and texture without imparting any undesirable flavour. Lastly, it is more stable and cost-effective than its counterparts. 
  • Galdieria Extract Blue: Extracted from red microalgae Galdieria, it is a sustainable and natural substitute for artificial food colors. For now, the FDA is fast-tracking approval of this pigment, and once done, it will be a safer alternative without the aforementioned health risks. 
  • Gardenia Blue: Derived from G. jasminoides fruits found in Vietnam, China, Japan, and Taiwan. It is already being used in a number of Asian snacks and has potential for wider applications in other kinds of snacks. 
  • Butterfly Pea Flower Extract: They are useful as a natural blue colorant, they have a longer shelf life, and they bloom all year. 

Natural Food Colors

Natural food colors are the pigments extracted from natural food substances. For example, anthocyanins derived from purple sweet potato, beetroot powder, paprika extract, hibiscus powder, annatto, etc, can be used to render color to food items. However, there are certain challenges associated with their use.

Read more about the Natural Food Coloring challenges and benefits

The Last Word

Though there are several natural and synthetic alternatives available to the present array of artificial food additives, most of them are currently being used in small batches or in limited quantities. The biggest challenge with natural alternatives is quantity; therefore, upscaling their production on an industrial level will require some strong R&D efforts from industry stakeholders.

The same stands true for synthetic alternatives, despite FDA fast-tracking their reviews and approvals; further studies are required to dive into their long-term use effects and what kind of innovative applications they can be used in. Strategic alliances and technology scouting will definitely help industry leaders resolve some of these complications. But for expert counsel and guidance on benchmarking regulatory frameworks and supporting technologies, our team is available to talk. 

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